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KMID : 0043320070300020260
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Archives of Pharmacal Research
2007 Volume.30 No. 2 p.260 ~ p.265
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Pharmacokinetics of Baicalein, Baicalin and Wogonin after Oral Administration of a Standardized Extract of Scutellaria baicalensis, PF-2405 in Rats
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Kim Young-Hoon
Jeong Dong-Won
Kim Youn-Chul
Sohn Dong-Hwan
Park Eun-Seok
Lee Hye-Suk
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Abstract
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The pharmacokinetics of active components such as baicalein, wogonin and oroxylin A were evaluated after oral administration of a purified extract of Scutellaria baicalensis GEORGI (PF- 2405) containing the high contents of baicalein, wogonin and oroxylin A to rats. Following oral administration of PF-2405 at 10, 20 and 40 mg/kg dose (equivalent to 4.5, 9.0 and 18 mg/kg baicalein), a major constituent baicalein and its active metabolite baicalin showed dose-linear pharmacokinetics as evidenced by unaltered dose-normalized AUC, dose-normalized Cmax, Ae0?0h and GI30h values. Following oral administration of PF-2405 at three doses (equivalent to 0.4, 0.8 and 1.6 mg/kg wogonin), dose-normalized Cmax and dose-normalized AUC were comparable between the 20 and 40 mg/kg PF2405 doses, but plasma concentrations of wogonin at 10 mg/kg of PF-2405 were not measurable as they were below limit of quantitation (LOQ; 18 pmol/mL). Following oral administration of PF-2405 at the three doses (equivalent to 1.5, 3.0 and 6.0 mg/kg oroxylin A), the concentrations of oroxylin A in plasma, urine and gastrointestine samples were below the assay LOQ (18 pmol/mL). Significant differences in AUCs, Ae0?0h and GI30h values for baicalein and baicalin were observed after oral administration of pure baicalein (18 mg/kg) and PF-2405 (40 mg/kg). The increases in AUCs of baicalein and baicalin after oral administration of PF-2405 may have been due to the significant decrease in GI30h values for baicalein.
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KEYWORD
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Standardized extract of Scutellaria baicalensis (PF-2405), Pharmacokinetics, Baicalein, Baicalin, Wogonin, Rats
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